Prof. Dr. Hans-Georg Schaible
Univ. Friedrich Schiller de Jena (Germany)
To present the idea that pain and disease can, in the light of current concepts, be understood only in the field of interoception of the body and are interconnected through the immune system; to know the autonomic spinal functions and spinal nociception in the patient; or discuss whether the “whole person” approach to treatment in manual medicine can be reconciled with the modern neurobiology of regulating body functions.
To present the idea that pain and disease can, in the light of current concepts, be understood only in the field of interoception of the body and are interconnected through the immune system
Hans-Georg Schaible is Professor of Neurophysiology at Jena University Hospital. His main interests throughout his research career have been centered around the neurobiology of pain, especially the mechanisms of joint pain; the interaction between the immune system and the nervous system; neural modulation of arthritis; and pain associated with osteoarthritis. He has taught physiology to university students of medicine, dentistry, molecular medicine, and pharmacy.
● To present the idea that pain and disease can, in the light of current concepts, be understood only in the field of interoception of the body and are interconnected through the immune system.
● To know the autonomic spinal functions and spinal nociception in the patient.
● To discuss whether the “whole person” approach to treatment in manual medicine can be reconciled with the modern neurobiology of regulating body functions.
NEUROIMMUNE CONNECTION IN PAIN AND DISEASE
1.- Nervous System and Pain
Lecture 1.0 Intro: concept of the course.
Lecture 1.1 Peripheral nociceptor.
1.1.1 Properties of nociceptors.
1.1.2 Interaction between nociceptors and surrounding tissues.
Lecture 1.2 Nociceptive processing in the spinal cord.
1.2.1 Synapsis and interneurones.
1.2.2 Ascending tracts and supraspinal targets.
1.2.3 Supraespinals reflexes.
Lecture 1.3 Generation of pain perception in the brain.
1.3.1 Sensory-discriminative processing (thalamic functions and brain areas involved in the detection of painful stimuli)
1.3.2 Emotional-discriminative processing (cortical and subcortical areas involved in the generation of the emotional response to nociceptive stimuli)
Lecture 1.4 Endogenous inhibition of pain.
1.4.1 Inhibitory circuits.
Lecture 1.5 Bio-psico-social model of pain.
Discussion
2.- Clinical States of Pain
Lecture 2.1 Nociceptive Pain.
2.1.1 Clinical characteristics and neural mechanisms.
Lecture 2.2 Neuropathic Pain.
2.2.1 Clinical characteristics and neural mechanisms.
Lecture 2.3 Role of comorbidities.
Discussion
3.- Interactions between Nociceptive System and Autonomic Nervous System
Lecture 3.1 Influences of the Sympathetic Nervous System.
Lecture 3.2 Influences of the Parasympathetic Nervous System
Discussion
4.- Interactions between Nociceptive System and Immune System
Lecture 4.1 Interaction locations in the Peripheral Nociceptive System.
Lecture 4.2 Interaction locations in the Central Nervous System.
Discussion
5.- Control of inflammation by the Nervous System
Lecture 5.1 Effects of the Sympathetic Nervous System on inflammation
5.1.1 Sympathetic effects on inflamed tissue.
5.1.2 Sympathetic effects on immune organs.
Lecture 5.2 Effects of the Parasympathetic Nervous System.
Lecture 5.3 Role of the Neuroendocrine System.
Discussion: In all the debate sessions the contributions of each class will be discussed in relation to its implications in clinical interventions in patients with pain, trying to link the basic scientific contribution with clinical evidence.
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